Orphan disease Lab UCLA

Thomas DrakeThomas Drake, MD

Integrating genetics and gene expression to study complex disease pathogenesis
Naturally occurring genetic variation among individuals affects many if not most complex biologic processes to some measurable degree. This variation can be exploited in experimental populations by integrating genetics and large scale gene expression analyses ("genetical genomics"), with measurements of the disease or process of interest. This combination allows the identification of causal relationships between genes and phenotypes, and the development of models of the complex interactions involved in disease pathogenesis. Continued >

Richard Gatti, MD

Molecular genetics, cancer genetics, immunology, DNA repair
Gatti is interested in translational research, including both the development of diagnostic assays and finding new drugs to treat genetic disorders. His research focuses on DNA repair disorders, using ataxia-telangiectasia (A-T) as the primary working model. The lab collaborates with investigators in many other countries. More Info >

Wayne Grody Wayne Grody, MD, PhD

Molecular genetics of metabolic and heritable neoplastic diseases
Utilizing modern molecular biologic techniques such as gene cloning, microarray hybridization, and gene transfer, my laboratory is involved in the elucidation, diagnosis and ultimately treatment of single-gene defects at the molecular level. Using human arginase deficiency, a defect in the urea cycle, as a model system, we are exploring, in close collaboration with the laboratory of Dr. Stephen Cederbaum, the molecular structure and tissue-specific regulation of the arginase genes in health and disease. Continued >

Siavash Kurdistani, MD

Cancer epigenetics
Chromatin is a highly condensed complex of nucleic acid and basic proteins whose fundamental subunit, the nucleosome, has the same type of design in all eukaryotes. The nucleosome contains ~200 bp of DNA wrapped around an octamer of histones consisting of two copies of each histone H2A, H2B, H3 and H4. All histones are modified by covalent linkage of...

Siavash Kurdistani
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