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Orphan disease Cystic fibrosis

Cystic fibrosis (CF) is an inherited condition that causes mucus to build up and clog some of the organs in the body, particularly in the lungs and pancreas. When mucus clogs the lungs, it can make breathing very difficult. The thick mucus also causes bacteria to get stuck in the airways, which causes inflammation and infections. These infections can cause chronic coughing, and wheezing. Over time, mucus buildup and infections can lead to permanent lung damage, including the formation of scar tissue (fibrosis) and cysts in the lungs. Mucus can also block the digestive tract and pancreas, leading to digestive problems. CF is caused by mutations in the CFTR gene and is inherited in an autosomal recessive pattern.

Last updated: 4/4/2013

References

  1. Cystic Fibrosis . Genetics Home Reference Web site. January 2008; Accessed 8/23/2011.
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Popular Q&A

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What is Cystic Fibrosis Disease?

Cystic fibrosis is a disease that affects the lungs and intestines. It makes your lungs produce a sticky mucus that makes it hard for you to breathe. There isn't a cure for cystic

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